Database
BC-TFdb Transcription factors drivers in Breast Cancer Database
| id |
Gene |
UniprotID |
PDBEntry |
Method |
Resolution |
Chain |
Positions |
download |
| 1 |
TP53 |
P04637 |
1TSR |
X-ray |
2.20 ? |
A/B/C |
94-312 |
download |
| 2 |
PIK3CA |
P42336 |
2RD0 |
X-ray |
3.05 ? |
A |
1-1068 |
download |
| 3 |
MYC |
P01106 |
5I50 |
X-ray |
2.70 ? |
A/B |
350-439 |
download |
| 4 |
CCND1 |
P24385 |
2W99 |
X-ray |
2.80 ? |
A |
1-271 |
download |
| 5 |
PTEN |
P60484 |
5BUG |
X-ray |
2.40 ? |
A/B/C/D |
14-351 |
download |
| 6 |
ERBB2/HER2 |
P04626 |
1MFG |
X-ray |
1.25 ? |
B |
1247-1255 |
download |
| 7 |
ZNF703/FGFR1 |
Q9H7S9 |
|
|
|
|
|
download |
| 8 |
GATA3 |
P23771 |
4HC7 |
X-ray |
2.65 ? |
A/B |
260-370 |
download |
| 9 |
RB1 |
P06400 |
4ELJ |
X-ray |
2.70 ? |
A |
53-787 |
download |
| 10 |
MAP3K1 |
Q13233 |
6WHB |
X-ray |
1.90 ? |
A |
542-888 |
download |
| 11 |
MAP2K4 |
P45985 |
3ALN |
X-ray |
2.30 ? |
A/B/C |
80-399 |
download |
| 12 |
ZNF217 |
O75362 |
2HU2 |
X-ray |
2.85 ? |
B |
752-760 |
download |
| 13 |
CDH1 |
P12830 |
2O72 |
X-ray |
2.00 ? |
A |
155-367 |
download |
| 14 |
MLL3/KMT2C |
Q8NEZ4 |
|
|
|
|
|
download |
| 15 |
ARID1B |
Q8NFD5 |
2EH9 |
X-ray |
2.00 ? |
A |
1041-1159 |
download |
| 16 |
CDKN2A |
P42771 |
1BI7 |
X-ray |
3.40 ? |
B |
1-156 |
download |
| 17 |
MLLT4 |
P55196 |
1T2M |
NMR |
|
A |
1003-1094 |
download |
| 18 |
AKT1/PKBa |
P31749 |
6HHI |
X-ray |
2.70 ? |
A |
2-446 |
download |
| 19 |
FBXW7 |
Q969H0 |
2OVP |
X-ray |
2.90 ? |
B |
263-707 |
download |
| 20 |
ARID1A |
O14497 |
6LTH |
Electron microscopy |
3.00 ? |
L |
Jan-85 |
download |
| 21 |
CCND3 |
P30281 |
3G33 |
X-ray |
3.00 ? |
B/D |
1-292 |
download |
| 22 |
CBFB |
Q13951 |
4N9F |
X-ray |
3.30 ? |
0/6/F/L/N/R/a/c/i/k/o/u |
1-170 |
download |
| 23 |
MDM2 |
Q00987 |
|
|
|
|
|
download |
| 24 |
CCNE1 |
P24864 |
1W98 |
X-ray |
2.15 ? |
B |
96-378 |
download |
| 25 |
CDKN2B |
P42772 |
|
|
|
|
|
download |
| 26 |
NCOR1 |
O75376 |
|
|
|
|
|
download |
| 27 |
SF3B1 |
O75533 |
5IFE |
X-ray |
3.10 ? |
C |
1-1304 |
download |
| 28 |
SPEN |
Q96T58 |
1OW1 |
X-ray |
1.80 ? |
A |
3470-3664 |
download |
| 29 |
TBX3 |
O15119 |
1H6F |
X-ray |
1.70 ? |
A/B |
101-311 |
download |
| 30 |
IGF1R |
P08069 |
6JK8 |
Electron microscopy |
4.70 ? |
A/B |
1-1367 |
download |
| 31 |
BRCA2 |
P51587 |
1N0W |
X-ray |
1.70 ? |
B |
1517-1551 |
download |
| 32 |
NF1 |
P21359 |
1NF1 |
X-ray |
2.50 ? |
A |
1198-1551 |
download |
| 33 |
PIK3R1 |
P27986 |
1PBW |
X-ray |
2.00 ? |
A/B |
105-319 |
download |
| 34 |
EGFR |
P00533 |
|
|
|
|
|
download |
| 35 |
KRAS |
P01116 |
|
|
|
|
|
download |
| 36 |
ESR1 |
P03372 |
1A52 |
X-ray |
2.80 ? |
A/B |
297-554 |
download |
| 37 |
FOXA1 |
P55317 |
|
|
|
|
|
download |
| 38 |
MED23 |
Q9ULK4 |
6H02 |
X-ray |
2.80 ? |
A |
1-1368 |
download |
| 39 |
CDK6 |
Q00534 |
1BI7 |
X-ray |
3.40 ? |
A |
1-326 |
download |
| 40 |
NOTCH2 |
Q04721 |
2OO4 |
X-ray |
2.00 ? |
A/B |
1423-1677 |
download |
| 41 |
AKT2/PKBb |
P31751 |
1GZN |
X-ray |
2.50 ? |
A |
146-480 |
download |
| 42 |
BRCA1 |
P38398 |
1JNX |
X-ray |
2.50 ? |
X |
1646-1859 |
download |
| 43 |
CTCF |
P49711 |
6QNX |
X-ray |
2.70 ? |
C |
1-727 |
download |
| 44 |
KDM6A |
O15550 |
6FUK |
X-ray |
2.00 ? |
A |
877-1401 |
download |
| 45 |
SETD2 |
Q9BYW2 |
4FMU |
X-ray |
2.10 ? |
A |
1434-1711 |
download |
| 46 |
CREBBP |
Q92793 |
3DWY |
X-ray |
1.98 ? |
A/B |
1081-1197 |
download |
| 47 |
DNMT3A |
Q9Y6K1 |
2QRV |
X-ray |
2.89 ? |
A/D/E/H |
627-912 |
download |
| 48 |
FOXP1 |
Q9H334 |
2KIU |
NMR |
|
A |
462-548 |
download |
| 49 |
MLL2 |
O14686 |
4ERQ |
X-ray |
1.91 ? |
D/E/F |
5333-5346 |
download |
| 50 |
RUNX1 |
Q01196 |
1H9D |
X-ray |
2.60 ? |
A/C |
50-183 |
download |
| 51 |
USP9X |
Q93008 |
5WCH |
X-ray |
2.50 ? |
A/B/C/D |
1551-197 |
download |
| 52 |
XBP1 |
P17861 |
6R5Q |
Electron microscopy |
3.00 ? |
1 |
237-260 |
download |
| 53 |
PDGFRA |
P16234 |
|
|
|
|
|
download |
| 54 |
ATR |
Q13535 |
5YZ0 |
Electron microscopy |
4.70 ? |
A/B |
Jan-44 |
download |
| 55 |
ERBB3 |
P21860 |
3LMG |
X-ray |
2.80 ? |
A/B |
684-1020 |
download |
| 56 |
FGFR2 |
P21802 |
1DJS |
X-ray |
2.40 ? |
A |
153-362 |
download |
| 57 |
PALB2 |
Q86YC2 |
2W18 |
X-ray |
1.90 ? |
A |
835-1186 |
download |
| 58 |
RHOA |
P61586 |
1FTN |
X-ray |
2.10 ? |
A |
1-193 |
download |
| 59 |
SMAD4 |
Q13485 |
1G88 |
X-ray |
3.00 ? |
A/B/C |
285-552 |
download |
| 60 |
ATM |
Q13315 |
5NP1 |
Electron microscopy |
5.70 ? |
A |
Jan-56 |
download |
| 61 |
ATRX |
P46100 |
3QLC |
X-ray |
2.50 ? |
A/B |
167-289 |
download |
| 62 |
AXIN1 |
O15169 |
1EMU |
X-ray |
1.90 ? |
A |
80-211 |
download |
| 63 |
BCOR |
Q6W2J9 |
4HPL |
X-ray |
2.00 ? |
A |
1634-1748 |
download |
| 64 |
CDKN1B |
P46527 |
5UQ3 |
X-ray |
3.60 ? |
C |
1-198 |
download |
| 65 |
CUX1 |
P39880 |
|
|
|
|
|
download |
| 66 |
GNAS |
Q5JWF2 |
|
|
|
|
|
download |
| 67 |
MLH1 |
P40692 |
3RBN |
X-ray |
2.16 ? |
A/B |
486-751 |
download |
| 68 |
NOTCH1 |
P46531 |
|
|
|
|
|
download |
| 69 |
PHF6 |
Q8IWS0 |
4NN2 |
X-ray |
1.47 ? |
A/B |
208-333 |
download |
| 70 |
SMARCA4 |
P51532 |
6LTJ |
Electron microscopy |
3.70 ? |
I |
1-1647 |
download |
| 71 |
STAG2 |
Q8N3U4 |
6QNX |
X-ray |
2.70 ? |
A |
1-1231 |
download |
| 72 |
ZFP36L1 |
Q07352 |
1W0V |
X-ray |
2.27 ? |
C |
325-333 |
download |
| 73 |
APC |
P25054 |
|
|
|
|
|
download |
| 74 |
CASP8 |
Q14790 |
3H11 |
X-ray |
1.90 ? |
B |
217-479 |
download |
| 75 |
CBLB |
Q13191 |
|
|
|
|
|
download |
| 76 |
CNOT3 |
O75175 |
4C0D |
X-ray |
3.20 ? |
C |
607-753 |
download |
| 77 |
ECT2L |
Q008S8 |
|
|
|
|
|
download |
| 78 |
MEN1 |
O00255 |
3U84 |
X-ray |
2.50 ? |
A/B |
2-615 |
download |
| 79 |
MSH2 |
P43246 |
2O8B |
X-ray |
2.75 ? |
A |
1-934 |
download |
| 80 |
NRAS |
P01111 |
3CON |
X-ray |
1.65 ? |
A |
1-172 |
download |
| 81 |
PBRM1 |
Q86U86 |
|
|
|
|
|
download |
| 82 |
PMS2 |
P54278 |
6MFQ |
X-ray |
2.60 ? |
A/B |
1-365 |
download |
| 83 |
STK11 |
Q15831 |
2WTK |
X-ray |
2.65 ? |
C/F |
43-347 |
download |
| 84 |
TET2 |
Q6N021 |
4NM6 |
X-ray |
2.03 ? |
A,A |
1129-1480,1844-1936 |
download |
| 85 |
ASXL1 |
Q8IXJ9 |
|
|
|
|
|
download |
| 86 |
BRAF |
P15056 |
6UAN |
Electron microscopy |
3.90 ? |
B/C |
1-766 |
download |
| 87 |
BUB1B |
O60566 |
5KHU |
Electron microscopy |
4.80 ? |
Q |
1-1050 |
download |
| 88 |
CIC |
Q96RK0 |
|
|
|
|
|
download |
| 89 |
ERCC4 |
Q92889 |
6SXA |
Electron microscopy |
3.60 ? |
F |
1-916 |
download |
| 90 |
HRAS |
P01112 |
1IOZ |
X-ray |
2.00 ? |
A |
1-171 |
download |
| 91 |
NF2 |
P35240 |
4ZRJ |
X-ray |
2.30 ? |
A,B |
1-320,506-595 |
download |
| 92 |
PRDM1 |
O75626 |
3DAL |
X-ray |
1.65 ? |
A/B |
38-223 |
download |
| 93 |
PREX2 |
Q70Z35 |
6BNM |
X-ray |
1.90 ? |
A |
219-377 |
download |
| 94 |
|
|
|
|
|
|
|
download |
>