1 |
TP53 |
DB05404 |
AZD 3355 |
investigational |
unknown |
|
2 |
TP53 |
DB08363 |
1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine |
experimental |
unknown |
|
3 |
TP53 |
DB00945 |
Acetylsalicylic acid |
approved, vet_approved |
unknown |
induceracetylation |
4 |
TP53 |
DB01593 |
Zinc |
approved, investigational |
unknown |
|
5 |
TP53 |
DB03347 |
Triethyl phosphate |
experimental |
unknown |
|
6 |
TP53 |
DB14487 |
Zinc acetate |
approved, investigational |
unknown |
|
7 |
TP53 |
DB14533 |
Zinc chloride |
approved, investigational |
unknown |
chaperone |
8 |
TP53 |
DB14548 |
Zinc sulfate, unspecified form |
approved, experimental |
unknown |
chaperone |
9 |
PIK3CA |
DB11772 |
Pilaralisib |
investigational |
unknown |
|
10 |
PIK3CA |
DB05241 |
XL765 |
investigational |
unknown |
|
11 |
PIK3CA |
DB08059 |
Wortmannin |
experimental |
unknown |
|
12 |
PIK3CA |
DB00201 |
Caffeine |
approved |
unknown |
inhibitor |
13 |
PIK3CA |
DB00171 |
ATP |
investigational, nutraceutical |
unknown |
|
14 |
PIK3CA |
DB12483 |
Copanlisib |
approved, investigational |
yes |
inhibitor |
15 |
PIK3CA |
DB12015 |
Alpelisib |
approved, investigational |
yes |
inhibitor |
16 |
MYC |
DB08813 |
Nadroparin |
approved, investigational |
unknown |
inhibitor |
17 |
MYC |
DB00945 |
Acetylsalicylic acid |
approved, vet_approved |
unknown |
downregulator |
18 |
CCND1 |
DB01169 |
Arsenic trioxide |
approved, investigational |
yes |
antagonist |
19 |
CCND1 |
DB11718 |
Encorafenib |
approved, investigational |
yes |
inhibitor |
20 |
CCND1 |
DB00945 |
Acetylsalicylic acid |
approved, vet_approved |
unknown |
downregulator |
21 |
CCND1 |
DB11752 |
Bryostatin 1 |
investigational |
unknown |
inhibitor |
22 |
PTEN |
DB04327 |
Phosphatidylethanolamine |
experimental |
unknown |
substrate |
23 |
ERBB2/HER2 |
DB01259 |
Lapatinib |
approved, investigational |
yes |
antagonist |
24 |
ERBB2/HER2 |
DB00072 |
Trastuzumab |
approved, investigational |
yes |
antibody |
25 |
ERBB2/HER2 |
DB04988 |
IGN311 |
investigational |
unknown |
|
26 |
ERBB2/HER2 |
DB11973 |
Tesevatinib |
investigational |
unknown |
|
27 |
ERBB2/HER2 |
DB05773 |
Trastuzumab emtansine |
approved, investigational |
yes |
antibody |
28 |
ERBB2/HER2 |
DB05944 |
Varlitinib |
investigational |
unknown |
|
29 |
ERBB2/HER2 |
DB11652 |
Tucatinib |
approved, investigational |
yes |
inhibitor |
30 |
ERBB2/HER2 |
DB06021 |
AV-412 |
investigational |
unknown |
|
31 |
ERBB2/HER2 |
DB06366 |
Pertuzumab |
approved |
yes |
inhibitor |
32 |
ERBB2/HER2 |
DB08916 |
Afatinib |
approved |
yes |
inhibitor |
33 |
ZNF703/FGFR1 |
DB00039 |
Palifermin |
approved |
unknown |
agonist |
34 |
ZNF703/FGFR1 |
DB05014 |
XL999 |
investigational |
unknown |
|
35 |
ZNF703/FGFR1 |
DB07525 |
3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine |
experimental |
unknown |
|
36 |
ZNF703/FGFR1 |
DB07840 |
(E)-[4-(3,5-Difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol |
experimental |
unknown |
|
37 |
ZNF703/FGFR1 |
DB08577 |
3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE |
experimental |
unknown |
|
38 |
ZNF703/FGFR1 |
DB02058 |
3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone |
experimental |
unknown |
|
39 |
ZNF703/FGFR1 |
DB08896 |
Regorafenib |
approved |
yes |
inhibitor |
40 |
ZNF703/FGFR1 |
DB08901 |
Ponatinib |
approved, investigational |
unknown |
inhibitor |
41 |
ZNF703/FGFR1 |
DB00398 |
Sorafenib |
approved, investigational |
yes |
inhibitor |
42 |
ZNF703/FGFR1 |
DB09078 |
Lenvatinib |
approved, investigational |
yes |
inhibitor |
43 |
GATA3 |
DB00349 |
Clobazam |
approved, illicit |
yes |
other |
44 |
GATA3 |
DB08848 |
Guvacine |
experimental |
unknown |
inhibitor |
45 |
RB1 |
DB00030 |
Insulin human |
approved, investigational |
unknown |
|
46 |
RB1 |
DB00071 |
Insulin pork |
approved |
unknown |
|
47 |
MAP3K1 |
DB06061 |
AZD-8330 |
investigational |
unknown |
|
48 |
MAP3K1 |
DB12010 |
Fostamatinib |
approved, investigational |
unknown |
inhibitor |
49 |
MAP3K1 |
DB11967 |
Binimetinib |
approved, investigational |
yes |
inhibitor |
50 |
MLL3/KMT2C |
DB14581 |
CPI-1205 |
investigational |
yes |
inhibitor |
51 |
MLL3/KMT2C |
DB12887 |
Tazemetostat |
approved, investigational |
yes |
inhibitor |
52 |
CDKN2A |
DB08818 |
Hyaluronic acid |
approved, vet_approved |
unknown |
binder |
53 |
CDKN2A |
DB09130 |
Copper |
approved, investigational |
unknown |
|
54 |
AKT1/PKBa |
DB02709 |
Resveratrol |
investigational |
unknown |
inhibitor |
55 |
AKT1/PKBa |
DB06641 |
Perifosine |
investigational |
unknown |
|
56 |
AKT1/PKBa |
DB07584 |
N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
experimental |
unknown |
|
57 |
AKT1/PKBa |
DB01863 |
Inositol 1,3,4,5-Tetrakisphosphate |
experimental |
unknown |
|
58 |
AKT1/PKBa |
DB01645 |
Genistein |
investigational |
unknown |
|
59 |
AKT1/PKBa |
DB06486 |
Enzastaurin |
investigational |
unknown |
|
60 |
AKT1/PKBa |
DB00171 |
ATP |
investigational, nutraceutical |
unknown |
|
61 |
AKT1/PKBa |
DB01169 |
Arsenic trioxide |
approved, investigational |
unknown |
inducer |
62 |
AKT1/PKBa |
DB05971 |
Archexin |
investigational |
unknown |
|
63 |
AKT1/PKBa |
DB07585 |
5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine |
experimental |
unknown |
|
64 |
MDM2 |
DB02872 |
Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone |
experimental |
unknown |
|
65 |
MDM2 |
DB04144 |
Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone |
experimental |
unknown |
|
66 |
MDM2 |
DB01593 |
Zinc |
approved, investigational |
unknown |
|
67 |
MDM2 |
DB14487 |
Zinc acetate |
approved, investigational |
unknown |
|
68 |
MDM2 |
DB14533 |
Zinc chloride |
approved, investigational |
unknown |
binder |
69 |
MDM2 |
DB14548 |
Zinc sulfate, unspecified form |
approved, experimental |
unknown |
binder |
70 |
SF3B1 |
DB14017 |
H3B-8800 |
investigational |
yes |
inhibitor |
71 |
IGF1R |
DB01277 |
Mecasermin |
approved, investigational |
yes |
agonist |
72 |
IGF1R |
DB04395 |
Phosphoaminophosphonic Acid-Adenylate Ester |
experimental |
unknown |
|
73 |
IGF1R |
DB00030 |
Insulin human |
approved, investigational |
unknown |
|
74 |
IGF1R |
DB00071 |
Insulin pork |
approved |
unknown |
|
75 |
IGF1R |
DB05023 |
ATL1101 |
investigational |
unknown |
|
76 |
IGF1R |
DB05184 |
XL228 |
investigational |
unknown |
|
77 |
IGF1R |
DB12250 |
Cixutumumab |
investigational |
unknown |
|
78 |
IGF1R |
DB05897 |
rhIGFBP-3 |
investigational |
unknown |
|
79 |
IGF1R |
DB06075 |
Linsitinib |
investigational |
unknown |
|
80 |
IGF1R |
DB06343 |
Teprotumumab |
approved, investigational |
unknown |
inhibitor |
81 |
IGF1R |
DB07156 |
(4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione |
experimental |
unknown |
|
82 |
IGF1R |
DB07474 |
3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE |
experimental |
unknown |
|
83 |
IGF1R |
DB12267 |
Brigatinib |
approved, investigational |
unknown |
inhibitor |
84 |
IGF1R |
DB09098 |
Somatrem |
approved, investigational, withdrawn |
yes |
|
85 |
IGF1R |
DB00046 |
Insulin lispro |
approved |
unknown |
|
86 |
IGF1R |
DB01307 |
Insulin detemir |
approved |
unknown |
|
87 |
IGF1R |
DB00047 |
Insulin glargine |
approved |
unknown |
|
88 |
IGF1R |
DB01306 |
Insulin aspart |
approved |
unknown |
|
89 |
IGF1R |
DB01309 |
Insulin glulisine |
approved |
unknown |
|
90 |
IGF1R |
DB09564 |
Insulin degludec |
approved |
unknown |
|
91 |
IGF1R |
DB14751 |
Mecasermin rinfabate |
approved |
yes |
agonist |
92 |
PIK3R1 |
DB01064 |
Isoprenaline |
approved, investigational |
unknown |
agonist |
93 |
PIK3R1 |
DB05210 |
SF1126 |
investigational |
unknown |
|
94 |
PIK3R1 |
DB06486 |
Enzastaurin |
investigational |
unknown |
|
95 |
PIK3R1 |
DB08059 |
Wortmannin |
experimental |
unknown |
|
96 |
EGFR |
DB15035 |
Zanubrutinib |
approved, investigational |
unknown |
inhibitor |
97 |
EGFR |
DB12202 |
Zalutumumab |
investigational |
yes |
antagonist |
98 |
EGFR |
DB05944 |
Varlitinib |
investigational |
unknown |
|
99 |
EGFR |
DB05294 |
Vandetanib |
approved |
unknown |
inhibitor |
100 |
EGFR |
DB07602 |
S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE |
experimental |
unknown |
|
101 |
EGFR |
DB05374 |
Rindopepimut |
investigational |
unknown |
|
102 |
EGFR |
DB05524 |
Pelitinib |
investigational |
unknown |
|
103 |
EGFR |
DB07662 |
PD-168393 |
experimental |
unknown |
|
104 |
EGFR |
DB01269 |
Panitumumab |
approved, investigational |
yes |
suppressor |
105 |
EGFR |
DB09330 |
Osimertinib |
approved |
yes |
inhibitor |
106 |
EGFR |
DB13164 |
Olmutinib |
investigational |
yes |
inhibitor |
107 |
EGFR |
DB11828 |
Neratinib |
approved, investigational |
yes |
inhibitor |
108 |
EGFR |
DB09559 |
Necitumumab |
approved, investigational |
yes |
antagonist |
109 |
EGFR |
DB05101 |
Matuzumab |
investigational |
unknown |
|
110 |
EGFR |
DB00281 |
Lidocaine |
approved, vet_approved |
unknown |
antagonist |
111 |
EGFR |
DB01259 |
Lapatinib |
approved, investigational |
yes |
antagonist |
112 |
EGFR |
DB04988 |
IGN311 |
investigational |
unknown |
|
113 |
EGFR |
DB11737 |
Icotinib |
experimental, investigational |
unknown |
antagonist |
114 |
EGFR |
DB00317 |
Gefitinib |
approved, investigational |
yes |
antagonist |
115 |
EGFR |
DB12010 |
Fostamatinib |
approved, investigational |
unknown |
inhibitor |
116 |
EGFR |
DB10772 |
Foreskin keratinocyte (neonatal) |
approved |
yes |
agonist |
117 |
EGFR |
DB00530 |
Erlotinib |
approved, investigational |
yes |
antagonist |
118 |
EGFR |
DB11731 |
Depatuxizumab mafodotin |
investigational |
no |
antibody |
119 |
EGFR |
DB11963 |
Dacomitinib |
approved, investigational |
yes |
inhibitor |
120 |
EGFR |
DB00002 |
Cetuximab |
approved |
yes |
antagonist |
121 |
EGFR |
DB05424 |
Canertinib |
investigational |
unknown |
|
122 |
EGFR |
DB12267 |
Brigatinib |
approved, investigational |
yes |
inhibitor |
123 |
EGFR |
DB06021 |
AV-412 |
investigational |
unknown |
|
124 |
EGFR |
DB03496 |
Alvocidib |
experimental, investigational |
unknown |
|
125 |
EGFR |
DB08916 |
Afatinib |
approved |
yes |
inhibitor |
126 |
EGFR |
DB15327 |
Abivertinib |
investigational |
yes |
inhibitor |
127 |
KRAS |
DB07771 |
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID |
experimental |
unknown |
|
128 |
KRAS |
DB07780 |
Farnesyl diphosphate |
experimental |
unknown |
|
129 |
KRAS |
DB15569 |
AMG-510 |
investigational |
yes |
inhibitor |
130 |
KRAS |
DB15568 |
MRTX849 |
investigational |
yes |
inhibitor |
131 |
ESR1 |
DB00255 |
Diethylstilbestrol |
approved, investigational |
yes |
agonist |
132 |
ESR1 |
DB00269 |
Chlorotrianisene |
investigational, withdrawn |
yes |
agonist |
133 |
ESR1 |
DB00286 |
Conjugated estrogens |
approved |
yes |
agonist |
134 |
ESR1 |
DB00481 |
Raloxifene |
approved, investigational |
yes |
agonist |
135 |
ESR1 |
DB00539 |
Toremifene |
approved, investigational |
yes |
modulator |
136 |
ESR1 |
DB00655 |
Estrone |
approved |
yes |
agonist |
137 |
ESR1 |
DB00783 |
Estradiol |
approved, investigational, vet_approved |
yes |
agonist |
138 |
ESR1 |
DB00823 |
Ethynodiol diacetate |
approved |
yes |
agonist |
139 |
ESR1 |
DB00882 |
Clomifene |
approved, investigational |
yes |
antagonistagonist |
140 |
ESR1 |
DB00890 |
Dienestrol |
approved, investigational |
yes |
agonist |
141 |
ESR1 |
DB00947 |
Fulvestrant |
approved, investigational |
yes |
antagonist |
142 |
ESR1 |
DB00977 |
Ethinylestradiol |
approved |
yes |
agonist |
143 |
ESR1 |
DB00304 |
Desogestrel |
approved |
yes |
agonist |
144 |
ESR1 |
DB00367 |
Levonorgestrel |
approved, investigational |
yes |
other/unknown |
145 |
ESR1 |
DB00396 |
Progesterone |
approved, vet_approved |
unknown |
agonistinhibitordownregulator |
146 |
ESR1 |
DB00603 |
Medroxyprogesterone acetate |
approved, investigational |
yes |
agonist |
147 |
ESR1 |
DB00957 |
Norgestimate |
approved, investigational |
yes |
agonist |
148 |
ESR1 |
DB01185 |
Fluoxymesterone |
approved, illicit |
yes |
antagonist |
149 |
ESR1 |
DB01196 |
Estramustine |
approved, investigational |
yes |
agonist |
150 |
ESR1 |
DB01406 |
Danazol |
approved |
yes |
agonist |
151 |
ESR1 |
DB01183 |
Naloxone |
approved, vet_approved |
no |
antagonistother/unknown |
152 |
ESR1 |
DB02615 |
Compound 19 |
experimental |
unknown |
|
153 |
ESR1 |
DB02715 |
Compound 18 |
experimental |
unknown |
|
154 |
ESR1 |
DB03742 |
Compound 4-D |
experimental |
unknown |
|
155 |
ESR1 |
DB03802 |
1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol |
experimental |
unknown |
|
156 |
ESR1 |
DB04468 |
Afimoxifene |
investigational |
unknown |
|
157 |
ESR1 |
DB04471 |
2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol |
experimental |
unknown |
|
158 |
ESR1 |
DB04575 |
Quinestrol |
approved |
yes |
agonistmodulator |
159 |
ESR1 |
DB00675 |
Tamoxifen |
approved |
yes |
antagonistagonist |
160 |
ESR1 |
DB05233 |
AP1081 |
investigational |
unknown |
|
161 |
ESR1 |
DB04938 |
Ospemifene |
approved, investigational |
yes |
antagonistagonist |
162 |
ESR1 |
DB01357 |
Mestranol |
approved |
yes |
agonist |
163 |
ESR1 |
DB04573 |
Estriol |
approved, investigational, vet_approved |
yes |
agonist |
164 |
ESR1 |
DB05662 |
NP-50301 |
investigational |
unknown |
|
165 |
ESR1 |
DB05487 |
Custirsen |
investigational |
unknown |
|
166 |
ESR1 |
DB05882 |
CHF 4227 |
investigational |
unknown |
|
167 |
ESR1 |
DB05966 |
TAS-108 |
investigational |
unknown |
|
168 |
ESR1 |
DB06202 |
Lasofoxifene |
approved, investigational |
yes |
antagonistagonistnegative modulator |
169 |
ESR1 |
DB06249 |
Arzoxifene |
approved, investigational |
unknown |
|
170 |
ESR1 |
DB06374 |
Elacestrant |
investigational |
unknown |
|
171 |
ESR1 |
DB01065 |
Melatonin |
approved, nutraceutical, vet_approved |
unknown |
antagonist |
172 |
ESR1 |
DB06871 |
17-METHYL-17-ALPHA-DIHYDROEQUILENIN |
experimental |
unknown |
|
173 |
ESR1 |
DB06898 |
4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol |
experimental |
unknown |
|
174 |
ESR1 |
DB06927 |
[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE |
experimental |
unknown |
|
175 |
ESR1 |
DB07086 |
4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL |
experimental |
unknown |
|
176 |
ESR1 |
DB07087 |
4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL |
experimental |
unknown |
|
177 |
ESR1 |
DB07195 |
4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL |
experimental |
unknown |
|
178 |
ESR1 |
DB07567 |
(2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL |
experimental |
unknown |
|
179 |
ESR1 |
DB07638 |
(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL |
experimental |
unknown |
|
180 |
ESR1 |
DB07678 |
(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL |
experimental |
unknown |
|
181 |
ESR1 |
DB07707 |
(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL |
experimental |
unknown |
|
182 |
ESR1 |
DB07708 |
3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL |
experimental |
unknown |
|
183 |
ESR1 |
DB07712 |
3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL |
experimental |
unknown |
|
184 |
ESR1 |
DB01645 |
Genistein |
investigational |
unknown |
|
185 |
ESR1 |
DB07932 |
dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate |
experimental |
unknown |
|
186 |
ESR1 |
DB07933 |
Erteberel |
experimental, investigational |
unknown |
|
187 |
ESR1 |
DB07991 |
N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE |
experimental |
unknown |
|
188 |
ESR1 |
DB08020 |
(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL |
experimental |
unknown |
|
189 |
ESR1 |
DB08047 |
4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol |
experimental |
unknown |
|
190 |
ESR1 |
DB08048 |
4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL |
experimental |
unknown |
|
191 |
ESR1 |
DB08320 |
DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE |
experimental |
unknown |
|
192 |
ESR1 |
DB08398 |
2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
investigational |
unknown |
|
193 |
ESR1 |
DB08595 |
4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL |
experimental |
unknown |
|
194 |
ESR1 |
DB08737 |
(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL |
experimental |
unknown |
|
195 |
ESR1 |
DB08773 |
2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol |
experimental |
unknown |
|
196 |
ESR1 |
DB01108 |
Trilostane |
approved, investigational, vet_approved, withdrawn |
yes |
allosteric modulator |
197 |
ESR1 |
DB01431 |
Allylestrenol |
experimental |
unknown |
agonist |
198 |
ESR1 |
DB04574 |
Estrone sulfate |
approved |
yes |
agonist |
199 |
ESR1 |
DB01708 |
Prasterone |
approved, investigational, nutraceutical |
unknown |
binder |
200 |
ESR1 |
DB06401 |
Bazedoxifene |
approved, investigational |
yes |
antagonistagonist |
201 |
ESR1 |
DB09317 |
Synthetic Conjugated Estrogens, A |
approved |
yes |
ligand |
202 |
ESR1 |
DB09318 |
Synthetic Conjugated Estrogens, B |
approved |
yes |
ligand |
203 |
ESR1 |
DB09070 |
Tibolone |
approved, investigational |
yes |
antagonistagonist |
204 |
ESR1 |
DB03467 |
Naringenin |
experimental |
unknown |
|
205 |
ESR1 |
DB06732 |
beta-Naphthoflavone |
experimental |
unknown |
|
206 |
ESR1 |
DB04216 |
Quercetin |
experimental, investigational |
unknown |
|
207 |
ESR1 |
DB09086 |
Eugenol |
approved |
unknown |
|
208 |
ESR1 |
DB02901 |
Stanolone |
illicit, investigational |
unknown |
|
209 |
ESR1 |
DB00624 |
Testosterone |
approved, investigational |
unknown |
inhibitor |
210 |
ESR1 |
DB00648 |
Mitotane |
approved |
unknown |
|
211 |
ESR1 |
DB02746 |
Phthalic Acid |
experimental |
unknown |
|
212 |
ESR1 |
DB00431 |
Lindane |
approved, withdrawn |
unknown |
|
213 |
ESR1 |
DB01593 |
Zinc |
approved, investigational |
unknown |
cofactor |
214 |
ESR1 |
DB00756 |
Hexachlorophene |
approved, withdrawn |
unknown |
|
215 |
ESR1 |
DB01878 |
Benzophenone |
experimental |
unknown |
|
216 |
ESR1 |
DB09535 |
Octocrylene |
approved, investigational |
unknown |
|
217 |
ESR1 |
DB01428 |
Oxybenzone |
approved, investigational |
unknown |
|
218 |
ESR1 |
DB11219 |
Enzacamene |
approved |
unknown |
|
219 |
ESR1 |
DB04930 |
Permethrin |
approved, investigational |
unknown |
|
220 |
ESR1 |
DB02757 |
Pyrazole |
experimental |
unknown |
|
221 |
ESR1 |
DB07931 |
Hexestrol |
withdrawn |
unknown |
|
222 |
ESR1 |
DB12450 |
Propyl Gallate |
investigational |
unknown |
|
223 |
ESR1 |
DB02709 |
Resveratrol |
investigational |
unknown |
|
224 |
ESR1 |
DB11478 |
Zeranol |
experimental, vet_approved |
unknown |
|
225 |
ESR1 |
DB09371 |
Norethynodrel |
approved |
unknown |
|
226 |
ESR1 |
DB02187 |
Equilin |
experimental |
unknown |
|
227 |
ESR1 |
DB11064 |
Homosalate |
approved, investigational |
unknown |
|
228 |
ESR1 |
DB00841 |
Dobutamine |
approved |
unknown |
|
229 |
ESR1 |
DB11541 |
Ractopamine |
vet_approved |
unknown |
|
230 |
ESR1 |
DB06710 |
Methyltestosterone |
approved |
unknown |
|
231 |
ESR1 |
|
|
|
|
|
232 |
ESR1 |
DB04824 |
Phenolphthalein |
approved, withdrawn |
unknown |
agonist |
233 |
ESR1 |
DB13869 |
2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol |
experimental |
unknown |
|
234 |
ESR1 |
DB13943 |
Testosterone cypionate |
approved |
unknown |
|
235 |
ESR1 |
DB13944 |
Testosterone enanthate |
approved |
unknown |
|
236 |
ESR1 |
DB13946 |
Testosterone undecanoate |
approved, investigational |
unknown |
|
237 |
ESR1 |
DB13951 |
Stanolone acetate |
experimental |
unknown |
|
238 |
ESR1 |
DB13952 |
Estradiol acetate |
approved, investigational, vet_approved |
yes |
agonist |
239 |
ESR1 |
DB13953 |
Estradiol benzoate |
approved, investigational, vet_approved |
yes |
agonist |
240 |
ESR1 |
DB13954 |
Estradiol cypionate |
approved, investigational, vet_approved |
yes |
agonist |
241 |
ESR1 |
DB13955 |
Estradiol dienanthate |
approved, investigational, vet_approved |
yes |
agonist |
242 |
ESR1 |
DB13956 |
Estradiol valerate |
approved, investigational, vet_approved |
yes |
agonist |
243 |
ESR1 |
DB09369 |
Polyestradiol phosphate |
approved |
yes |
agonist |
244 |
ESR1 |
DB11619 |
Gestrinone |
approved |
unknown |
antagonistagonist |
245 |
ESR1 |
DB14487 |
Zinc acetate |
approved, investigational |
unknown |
|
246 |
ESR1 |
DB14533 |
Zinc chloride |
approved, investigational |
unknown |
binder |
247 |
ESR1 |
DB14641 |
Estriol tripropionate |
experimental |
yes |
|
248 |
ESR1 |
DB14548 |
Zinc sulfate, unspecified form |
approved, experimental |
unknown |
binder |
249 |
ESR1 |
DB15690 |
Fluoroestradiol F-18 |
approved |
unknown |
binder |
250 |
CDK6 |
DB03496 |
Alvocidib |
experimental, investigational |
unknown |
|
251 |
CDK6 |
DB07379 |
(2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol |
experimental |
unknown |
|
252 |
CDK6 |
DB07795 |
Fisetin |
experimental |
unknown |
|
253 |
CDK6 |
DB09073 |
Palbociclib |
approved, investigational |
yes |
inhibitor |
254 |
CDK6 |
DB11730 |
Ribociclib |
approved, investigational |
yes |
antagonistinhibitor |
255 |
CDK6 |
DB12001 |
Abemaciclib |
approved, investigational |
yes |
inhibitor |
256 |
AKT2/PKBb |
DB07812 |
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide |
experimental |
unknown |
|
257 |
AKT2/PKBb |
DB07859 |
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE |
experimental |
unknown |
|
258 |
AKT2/PKBb |
DB07947 |
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE |
experimental |
unknown |
|
259 |
AKT2/PKBb |
DB08073 |
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE |
experimental |
unknown |
|
260 |
CREBBP |
DB08655 |
9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE |
experimental |
unknown |
|
261 |
DNMT3A |
DB00721 |
Procaine |
approved, investigational, vet_approved |
unknown |
inhibitor |
262 |
|
DB01262 |
Decitabine |
approved, investigational |
unknown |
inhibitor |
263 |
PDGFRA |
DB01268 |
Sunitinib |
approved, investigational |
yes |
inhibitor |
264 |
PDGFRA |
DB00619 |
Imatinib |
approved |
unknown |
antagonist |
265 |
PDGFRA |
DB00102 |
Becaplermin |
approved, investigational |
unknown |
|
266 |
PDGFRA |
DB12742 |
Amuvatinib |
investigational |
unknown |
|
267 |
PDGFRA |
DB05146 |
XL820 |
investigational |
unknown |
|
268 |
PDGFRA |
DB06043 |
Olaratumab |
approved, investigational |
yes |
antagonist |
269 |
PDGFRA |
DB06589 |
Pazopanib |
approved |
yes |
inhibitor |
270 |
PDGFRA |
DB06595 |
Midostaurin |
approved, investigational |
yes |
antagonistinhibitor |
271 |
PDGFRA |
DB08896 |
Regorafenib |
approved |
yes |
inhibitor |
272 |
PDGFRA |
DB08901 |
Ponatinib |
approved, investigational |
unknown |
inhibitor |
273 |
PDGFRA |
DB09078 |
Lenvatinib |
approved, investigational |
yes |
inhibitor |
274 |
PDGFRA |
DB09079 |
Nintedanib |
approved |
yes |
inhibitor |
275 |
PDGFRA |
DB10772 |
Foreskin keratinocyte (neonatal) |
approved |
yes |
agonist |
276 |
PDGFRA |
DB12010 |
Fostamatinib |
approved, investigational |
unknown |
inhibitor |
277 |
PDGFRA |
DB12147 |
Erdafitinib |
approved, investigational |
unknown |
substrate |
278 |
PDGFRA |
DB14840 |
Ripretinib |
approved |
yes |
inhibitor |
279 |
PDGFRA |
DB14840 |
Ripretinib |
approved |
unknown |
inhibitor |
280 |
FGFR2 |
DB00039 |
Palifermin |
approved |
yes |
agonistbinder |
281 |
FGFR2 |
DB02491 |
4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine |
experimental |
unknown |
|
282 |
FGFR2 |
DB02058 |
3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone |
experimental |
unknown |
|
283 |
FGFR2 |
DB01041 |
Thalidomide |
approved, investigational, withdrawn |
yes |
antagonist |
284 |
FGFR2 |
DB08896 |
Regorafenib |
approved |
yes |
inhibitor |
285 |
FGFR2 |
DB08901 |
Ponatinib |
approved, investigational |
unknown |
inhibitor |
286 |
FGFR2 |
DB09078 |
Lenvatinib |
approved, investigational |
yes |
inhibitor |
287 |
FGFR2 |
DB09079 |
Nintedanib |
approved |
yes |
inhibitor |
288 |
FGFR2 |
DB01901 |
Sucrosofate |
experimental |
unknown |
ligand |
289 |
FGFR2 |
DB01109 |
Heparin |
approved, investigational |
unknown |
|
290 |
RHOA |
DB04315 |
Guanosine-5'-Diphosphate |
experimental |
unknown |
|
291 |
ATM |
DB00201 |
Caffeine |
approved |
unknown |
inhibitor |
292 |
ATRX |
DB05210 |
SF1126 |
investigational |
unknown |
|
293 |
ATRX |
DB00201 |
Caffeine |
approved |
unknown |
inhibitor |
294 |
AXIN1 |
DB04447 |
1,4-Dithiothreitol |
experimental |
unknown |
|
295 |
CASP8 |
DB12651 |
Bardoxolone |
investigational |
unknown |
|
296 |
CASP8 |
DB11752 |
Bryostatin 1 |
investigational |
unknown |
inhibitor |
297 |
PMS2 |
DB02930 |
Adenosine 5'-[gamma-thio]triphosphate |
experimental |
unknown |
|
298 |
BRAF |
DB00398 |
Sorafenib |
approved, investigational |
yes |
inhibitor |
299 |
BRAF |
DB05190 |
XL281 |
investigational |
unknown |
|
300 |
BRAF |
DB05984 |
RAF-265 |
investigational |
unknown |
|
301 |
BRAF |
DB06999 |
PLX-4720 |
experimental |
unknown |
|
302 |
BRAF |
DB07000 |
N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide |
experimental |
unknown |
|
303 |
BRAF |
DB08553 |
(1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime |
experimental |
unknown |
|
304 |
BRAF |
DB08881 |
Vemurafenib |
approved |
yes |
inhibitor |
305 |
BRAF |
DB08896 |
Regorafenib |
approved |
yes |
inhibitor |
306 |
BRAF |
DB08912 |
Dabrafenib |
approved, investigational |
yes |
antagonistinhibitor |
307 |
BRAF |
DB12010 |
Fostamatinib |
approved, investigational |
unknown |
inhibitor |
308 |
HRAS |
DB02210 |
Hexane-1,6-Diol |
experimental |
unknown |
|
309 |
HRAS |
DB03226 |
Trifluoroethanol |
experimental |
unknown |
|
310 |
HRAS |
DB04137 |
Guanosine-5'-Triphosphate |
experimental |
unknown |
|
311 |
HRAS |
DB04315 |
Guanosine-5'-Diphosphate |
experimental |
unknown |
|
312 |
HRAS |
DB08751 |
N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE |
experimental |
unknown |
|
313 |
DNMT3A |
DB00721 |
Procaine |
approved, investigational, vet_approved |
unknown |
inhibitor |
314 |
DNMT3A |
DB01262 |
Decitabine |
approved, investigational |
unknown |
inhibitor |
315 |
SMAD2 |
DB04522 |
Dexfosfoserine |
experimental |
unknown |
|
316 |
NR1I2 |
DB00783 |
Estradiol |
approved, investigational, vet_approved |
unknown |
binder |
317 |
NR1I2 |
DB00977 |
Ethinylestradiol |
approved |
unknown |
agonist |
318 |
NR1I2 |
DB01892 |
Hyperforin |
nutraceutical |
unknown |
|
319 |
NR1I2 |
DB04466 |
SR12813 |
experimental |
unknown |
|
320 |
NR1I2 |
DB00163 |
Vitamin E |
approved, nutraceutical, vet_approved |
unknown |
|
321 |
NR1I2 |
DB01045 |
Rifampicin |
approved |
unknown |
agonist |
322 |
NR1I2 |
DB01220 |
Rifaximin |
approved, investigational |
no |
agonist |
323 |
NR1I2 |
DB07080 |
TO-901317 |
experimental |
unknown |
|
324 |
NR1I2 |
DB00530 |
Erlotinib |
approved, investigational |
yes |
agonist |
325 |
NR1I2 |
DB08864 |
Rilpivirine |
approved |
unknown |
agonist |
326 |
STAT5B |
DB01254 |
Dasatinib |
approved, investigational |
unknown |
inhibitor |
327 |
RAD51 |
DB12742 |
Amuvatinib |
investigational |
unknown |
|
328 |
RAD51 |
DB04395 |
Phosphoaminophosphonic Acid-Adenylate Ester |
experimental |
unknown |
|
329 |
POU2F1 |
DB01203 |
Nadolol |
approved |
unknown |
substrate |
330 |
SRSF1 |
DB09130 |
Copper |
approved, investigational |
unknown |
|
331 |
NR1H3 |
DB07080 |
TO-901317 |
experimental |
unknown |
|
332 |
NR1H3 |
DB07929 |
N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE |
experimental |
unknown |
|
333 |
NR1H3 |
DB08063 |
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE |
experimental |
unknown |
|
334 |
NR1H3 |
DB08175 |
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID |
experimental |
unknown |
|
335 |
NR1H3 |
DB13174 |
Rhein |
experimental |
unknown |
inhibitor |
336 |
NR1H3 |
DB11994 |
Diacerein |
approved, investigational |
unknown |
inhibitor |
337 |
FOS |
DB08813 |
Nadroparin |
approved, investigational |
unknown |
inhibitor |
338 |
NR1I3 |
DB01889 |
16,17-Androstene-3-Ol |
experimental |
unknown |
|
339 |
NR1I3 |
DB07557 |
3,20-Pregnanedione |
experimental |
unknown |
|
340 |
NR1I3 |
DB01708 |
Prasterone |
approved, investigational, nutraceutical |
unknown |
activator |
341 |
NR1I3 |
DB00737 |
Meclizine |
approved |
unknown |
inverse agonist |
342 |
NR1I3 |
DB04540 |
Cholesterol |
approved, investigational |
unknown |
|
343 |
NR1I3 |
DB00366 |
Doxylamine |
approved, vet_approved |
unknown |
|
344 |
NR1I3 |
DB07931 |
Hexestrol |
withdrawn |
unknown |
|
345 |
NR1I3 |
DB01026 |
Ketoconazole |
approved, investigational |
unknown |
|
346 |
NR1I3 |
DB00836 |
Loperamide |
approved |
unknown |
|
347 |
NR1I3 |
DB01620 |
Pheniramine |
approved |
unknown |
|
348 |
|
|
|
|
|
|
349 |
|
|
|
|
|
|
350 |
|
|
|
|
|
|
351 |
|
|
|
|
|
|
352 |
|
|
|
|
|
|
353 |
|
|
|
|
|
|
354 |
|
|
|
|
|
|
355 |
|
|
|
|
|
|
356 |
|
|
|
|
|
|
357 |
|
|
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|
|
|
358 |
|
|
|
|
|
|
359 |
|
|
|
|
|
|
360 |
|
|
|
|
|
|
361 |
|
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|
|
|
|
362 |
|
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|
|
|
|
363 |
|
|
|
|
|
|
364 |
|
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|
|
|
365 |
|
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|
|
|
366 |
|
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|
|
|
367 |
|
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|
|
|
368 |
|
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|
|
|
369 |
|
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|
|
|
|
370 |
|
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|
|
371 |
|
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|
372 |
|
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|
373 |
|
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|
374 |
|
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|
375 |
|
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|
376 |
|
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|
377 |
|
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|
|
378 |
|
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|
|
379 |
|
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|
|
380 |
|
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|
381 |
|
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|
382 |
|
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|
383 |
|
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|
384 |
|
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|
385 |
|
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|
|
386 |
|
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|
|
387 |
|
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|
|
388 |
|
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|
389 |
|
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|
390 |
|
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|
391 |
|
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|
392 |
|
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|
393 |
|
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|
394 |
|
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|
395 |
|
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|
396 |
|
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|
397 |
|
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|
398 |
|
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|
399 |
|
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|
400 |
|
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|
401 |
|
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|
402 |
|
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|
403 |
|
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|
404 |
|
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